News & Publications

Century Health, a pioneer in applying AI to real-world clinical data to accelerate research, today announced an oversubscribed $5 million seed round led by Origin Ventures, with participation from new investors InnovateHealth Ventures, 25madison, and Next Play Ventures, and continuing investors 2048 Ventures and Alumni Ventures.

Inside Century Health's approach to extracting reliable, structured insights from the messy, multimodal world of clinical data, and how we use reinforcement learning to continuously improve our models.

CHARM (Century Health Abstraction and Retrieval Model) automates the extraction of structured variables from unstructured clinical records using Large Language Model (LLM) reasoning and clinical Natural Language Processing (NLP). The result: highly accurate, scalable data abstraction that enables RWE studies to move faster and at lower cost than traditional methods.

Century Health, an AI company focused on real-world clinical data, announced a partnership with Dallas Renal Group to better understand rare kidney diseases, where diagnoses and signs of disease progression often end up buried in doctors' notes and pathology reports.

Century Health, a pioneer in applying AI to real-world clinical data to accelerate research, and Tessel Biosciences, a biotechnology company that combines human organoids and machine learning to model chronic disease, today announced a collaboration through which Tessel will leverage Century Health's COPD real-world dataset to characterize key patient subgroups that can benefit from its programs in development for muco-obstructive lung disease.

Century Health and Balboa Nephrology have announced they are partnering to apply AI to real-world data (RWD), transforming unstructured clinical information into actionable evidence to advance research, improve patient care, and accelerate drug development for chronic kidney disease and related conditions.

Integrating Century Health's novel large language model (LLM) with electronic health records (EHRs) rapidly delivered 130k+ clinical variables to advance research into MS treatment and care

By joining Datavant’s Lighthouse Partner Program, Century Health enables researchers to discover and assess high-quality, longitudinal clinical data in minutes—not months—without accessing or transferring sensitive patient information.

Century Health, a pioneer in applying AI to real-world data to accelerate research, today announced it is one of the first data providers to join Datavant Connect powered by AWS Clean Rooms, through its Lighthouse Partner Program.

The untapped potential of electronic health records has long been recognized in clinical research, but extracting meaningful insights from this treasure trove of data has remained an elusive challenge—until now.

AI platform will examine electronic records, curate data for researchers

Century Health, an AI-enabled real-world evidence platform, has formed a strategic partnership with neurology practice Nira Medical to transform electronic health record (EHR) data from multiple sclerosis (MS) patients into actionable insights.

Century Health’s AI platform will create structured datasets based on multiple sclerosis patient data collected from Nira Medical’s network of clinics.

The oversubscribed seed round will be used to grow the company's data network, disease-specific AI capabilities and collaborations with life sciences companies.

IgA nephropathy (IgAN) and related glomerular diseases (GD) are increasingly being evaluated under a more stringent evidence framework than in the past. Regulatory agencies, clinicians, and payers now focus on two endpoints when assessing disease progression and treatment value: early proteinuria reduction as an indicator of near-term risk, and longitudinal eGFR slope as a measure of sustained kidney preservation.

Large language models used for clinical abstraction are sensitive to prompt wording, yet most work treats prompts as fixed and studies uncertainty in isolation. We argue these should be treated jointly. Across two clinical tasks (MedAlign applicability/correctness and MS subtype abstraction) and multiple open and proprietary models, we measure prompt sensitivity via flip rates and relate it to calibration and selective prediction. We find that higher accuracy does not guarantee prompt stability, and that models can appear well-calibrated yet remain fragile to paraphrases. We propose a dual-objective prompt optimization loop that jointly targets accuracy and stability, showing that explicitly including a stability term reduces flip rates across tasks and models, sometimes at modest accuracy cost. Our results suggest prompt sensitivity should be an explicit objective when validating clinical LLM systems.

Century Health, a pioneer in applying AI to real-world clinical data to accelerate research, and Dallas Renal Group, one of the largest nephrology practices in Texas, today announced a partnership aimed at improving identification and understanding of rare glomerular diseases including IgA nephropathy (IgAN) and C3 glomerulopathy.

Century Health, a pioneer in applying AI to real-world data to accelerate research and advance therapeutics, and Memory Treatment Centers, a national leader in neurocognitive disease care, today announced a partnership to transform unstructured clinical data into research-grade real-world evidence. This enables rapid understanding of disease progression and how novel therapies for Alzheimer's disease perform outside clinical trials.

Century Health, a pioneer in applying AI to real-world data to accelerate research, and Balboa Nephrology, one of the nation's largest independent nephrology practices, today announced a partnership to make high-value real-world data (RWD) usable for clinical research and drug development in chronic kidney disease (CKD).

The partnership will draw on EHR data to gain insights into the progression and treatment of COPD and asthma.

While barriers to RWD remain, its use in clinical trials increased in 2024, GlobalData analysis shows.

Century Health, a pioneer in applying AI to real-world data to accelerate research, and Nimbus Health, a technology-driven pulmonary care provider transforming how lung conditions are managed, today announced a partnership to develop high-quality, real-world datasets for serious respiratory diseases.

The partnership between Century Health and Nira Medical uses AI to transform electronic health record (EHR) data into actionable insights, advancing multiple sclerosis (MS) research and care.

Century Health, a provider in applying artificial intelligence (AI) to real-world data for research acceleration, and Nira Medical, a national leader in neurological care delivery, announced a strategic partnership to advance the understanding of multiple sclerosis (MS) and improve patient outcomes.

Century Health, a pioneer in applying AI to real-world data to accelerate research, and Nira Medical, a national leader in delivering neurological care, today announced a partnership to curate data from more than 3,000 patients with multiple sclerosis to advance the understanding of the disease and treatment outcomes.

Century Health is a new startup also getting in on the action. It’s applying AI to clinical data to uncover new applications for drugs. It’s working with pharmaceutical companies and researchers, initially at Yale and UC San Diego, to identify and commercialize the next breakthrough for diseases, like Alzheimer’s, that affect tens of millions of patients.